General Information

  • ID:  hor002936
  • Uniprot ID:  P35904
  • Protein name:  Achatin-1
  • Gene name:  NA
  • Organism:  Lissachatina fulica (Giant African land snail) (Achatina fulica)
  • Family:  NA
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Lissachatina (genus), Achatinidae (family), Achatinoidea (superfamily), Helicina, Stylommatophora (order), Eupulmonata (superorder), Panpulmonata, Euthyneura, Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  NA

Sequence Information

  • Sequence:  GFAD
  • Length:  4
  • Propeptide:  GFAD
  • Signal peptide:  NA
  • Modification:  T2 D-phenylalanine
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Neuroexcitatory peptide; increases the impulse frequency and produces a spike broadening of the identified heart excitatory neuron (PON); also enhances the amplitude and frequency of the heart beat. Has also an effect on several other muscles.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor002936_AF2.pdbhor002936_ESM.pdb

Physical Information

Mass: 46211 Formula: C18H24N4O7
Absent amino acids: CEHIKLMNPQRSTVWY Common amino acids: ADFG
pI: 3.75 Basic residues: 0
Polar residues: 1 Hydrophobic residues: 2
Hydrophobicity: 17.5 Boman Index: -299
Half-Life: 30 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 25
Instability Index: -1372.5 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  2597281
  • Title:  Achatin-I, an endogenous neuroexcitatory tetrapeptide from Achatina fulica Ferussac containing a D-amino acid residue.
  • PubMed ID:  1675568
  • Title:  Purification of achatin-I From the Atria of the African Giant Snail, Achatina Fulica, and Its Possible Function.
  • PubMed ID:  8853710
  • Title:  Crystal structure and molecular conformation of achatin-I (H-Gly-D-Phe-Ala-Asp-OH), an endogenous neuropeptide containing a D-amino acid residue.